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Chemical Simulations Group has the experience to perform detailed
exon/intron analyses to reveal detailed gene structure. In
addition to exon insertions and deletions, the example below
demonstrates an altered exon edge resulting in exons 4a and 4b.
This is an in phase altered exon edge resulting in two protein isoforms
from a single exon. aggtctgtgcgtgtcctttgttgccaggattgccctgccaagctaaccgg
gttgtgcttcgcgtttcagACTTCTGCCTGGTGTCGAAGGTGGTGGGCAG
EXON 2
ATGCCGGGCCTCCATGCCTAGGTGGTGGTACAATGTCACTGACGGATCCT
GCCAGCTGTTTGTGTATGGGGGCTGTGACGGAAACAGCAATAATTACCTG
ACCAAGGAGGAGTGCCTCAAGAAATGTGCCACTGTCACAGgtgagatggc
agtagttggagcttttgtttttttcctttttttttttttttttttttttt
...
...
gctcattctttgtccctggcagtctctcgaaagctctttcactgtgctgt
ttctttgtccccttgcagAGAATGCCACGGGTGACCTGGCCACCAGCAGG
EXON 3
AATGCAGCGGATTCCTCTGTCCCAAGTGgtaggttcttaaagagacccgc
gatggagtgaggccaccggatgggtcattgtgaaaggacacttgtcattt
...
...
ggcccttccagacccagacccagctaggcctgtgtcctgtgtccggccca
gcctccctaacacagatgtttgtgtttcagCTCCCAGAAGGCAGGATTCT
EXON 4a & 4b
GAAGACCACTCCAGCGATATGTTCAACTATGAAGGTAAAACTCCAAAGAG
GCCAGgtgcggtggctcacacctgtaatcccagcgctttgggaggctgag
gtgggcggatcacgaggtcaggatatcaagaccatcctaacatggtgaaa
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